What is THC remediation?

THC remediation is the process of removing or reducing the psychoactive THC from hemp-derived CBD extracts or products. THC molecules are targeted and removed using highly developed scientific methods and equipment. The result is a purified oil, void of THC and rich in CBD, that maintains its original plant profile, ideally with minor cannabinoid ratios intact.

Why is remediation needed?

Hemp plants naturally produce a small amount of THC. The allowable level of THC in the hemp plant at harvest can be as high as 1.0%. Extraction of the oils from the plant biomass results in concentration of the cannabinoids, often spiking the THC levels in the oil as high as 5% or more.

Federal regulations limit the allowable amount of THC in CBD products to 0.3%. For many consumers and some specific states with more stringent laws, however, the presence of any THC is unacceptable.  Manufacturers basically have 2 options – dilution or remediation.

Dilution is not remediation

Dilution is the process of mixing the CBD crude (containing THC) with another oil, such as MCT, at a ratio that reduces the total THC content in the end product below the legal limit.  This process is not specific to THC however.  Dilution reduces all cannabinoids proportionally making it difficult to increase CBD concentration levels in products and impossible to eliminate THC altogether.

Remediation options

Remediation targets THC specifically, providing a mechanism to reduce or eliminate THC while retaining CBD and most of the other broad-spectrum cannabinoids in the oil.  This allows manufacturers to make products of varying CBD concentrations without the psychoactive side effects.

Within remediation, there are 3 main process categories, chromatography (i.e., separation), conversion, and harmonic distillation.

Historically chromatography has been the most common method.  There are multiple forms of chromatography and the most popular for THC remediation is reverse-phase flash chromatography.  Reverse-phase, as opposed to normal phase, uses polar solvents such as Ethanol and water. The solvents used for normal-phase tend to be much harsher and would introduce additional risk.  The ‘flash’ part of the chromatography indicates that pressure is applied to the system to accelerate the separation process.  While Chromatography is a very effective method for molecular separation, there are many downsides to chromatography including, high CBD loss rates (often as much as 30% or more), operation requires highly skilled staff, operating costs are very high, and to scale up, all of these costs are amplified many times, often resulting in solutions with combined CapEx/OpEx into the tens of millions of dollars.

Harmonic distillation uses a proprietary combination of temperature, pressure/vacuum, stirring, water, and sophisticated software controls to remove the THC from winterized crude.  The promoted benefits of this process include a simple user interface, reducing the operator skill level required, much lower acquisition and operating costs when compared to chromatography, and a relatively small physical footprint in the lab.  CBD loss rates, according to user reports on various industry forums, are in the 15% to 20% range when processing to compliant product.  Batch sizes are limited to 70 liters and take approximately 24 hours to get to compliant THC levels.  Run times can be increased to reach non-detect THC levels however this typically results in increased CBD loss as well.

Conversion methods use heat, light, pressure/vacuum, stirring, or some combination of these parameters to degrade or convert THC into other molecules.  These systems, when compared to chromatography are much simpler to use and are much less expensive to both acquire and operate. Depending on the system, CBD loss rates are typically in the 15% to 30%+ range and processing capacities are limited to 50 to 100 liters per day to achieve THC levels compliant with the 0.3% limit.  To achieve “ND” THC levels, most systems generally require a second pass or additional run-time, making the effective daily capacities roughly half of the published values when ND is required.

In order to scale up, for most of these systems the only way to increase capacity is to add more units. This takes up more square footage in the facility and requires more labor to manage the additional units making this impractical for high-capacity processors.


The ENTEXS RMD-T series equipment falls into the conversion category of remediation processes.  To our knowledge, these are the only systems that have been able to physically demonstrate low loss rate remediation at a large enough scale to support high-capacity production.  These systems have demonstrated CBD loss rates consistently below 5% on batches as small as a few liters and as large as a few thousand liters.

The RMD-T series utilizes a very simple user interface that can be operated by a general lab technician.  Lab operators will be trained to perform all in-process testing and monitoring in-house in real-time, keeping your operation efficient and productive.

To further support product quality and safety standards, the process utilizes a proprietary solvent which is 100% USDA Organic under the National Organic Program and the system is designed and built to comply with CGMP standards.

In Conclusion

Modern remediation solutions promise significant advantages over traditional chromatography.  Upon initial review, there appears to be several options to choose from.  It is important to review each system in detail and understand the strengths and weaknesses.  As you work through your own evaluation, there are a few things you can do to make sure you understand exactly what you are getting.  Requesting COAs of product before and after remediation will allow you to verify the CBD loss rates of the process.  In this comparison, make sure that the batch size of the sample data is representative of what you expect your typical batch size will be.  In addition to reviewing the COA, have the manufacturer perform a test run on a sample of your crude to verify run times and end-product quality. And finally, it is important to verify that the systems and solvents will support your plans for CGMP, organic, or other industry standards.

There are multiple options now available for remediation, but as you can see, not all are created equal. Be diligent, understand the real operational details, and make the best decision.

This content is provided as a membership benefit to our valuable business level members. Due to several factors including the variances in state hemp laws and the differences in interpretation of federal law, NHA makes no warrants of the legality, efficacy or safety of any product, service or statement made by any third party.

We encourage all members and the general public to do their own due diligence on any business or product, and understanding their state’s and federal laws, before choosing to purchase any product or contracting for any service